PUBLICATION

Cardiac regeneration in model organisms

Authors
Gamba, L., Harrison, M., and Lien, C.L.
ID
ZDB-PUB-140410-24
Date
2014
Source
Current Treatment Options in Cardiovascular Medicine   16(3): 288 (Review)
Registered Authors
Lien, Ching-Ling (Ellen)
Keywords
none
MeSH Terms
none
PubMed
24496965 Full text @ Curr. Treat. Options Cardiovasc. Med.
Abstract

Myocardial infarction is the most common cause of cardiac injury in humans and results in acute loss of large numbers of myocardial cells. Unfortunately, the mammalian heart is unable to replenish the cells that are lost following a myocardial infarction and an eventual progression to heart failure can often occur as a result. Regenerative medicine based approaches are actively being developed; however, a complete blueprint on how mammalian hearts can regenerate is still missing. Knowledge gained from studying animal models, such as zebrafish, newt, and neonatal mice, that can naturally regenerate their hearts after injury have provided an understanding of the molecular mechanisms involved in heart repair and regeneration. This research offers novel strategies to overcome the limited regenerative response observed in human patients.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping