PUBLICATION

Hormetic effect induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos

Authors
Choi, V.W., Cheung, A.L., Cheng, S.H., and Yu, P.K.
ID
ZDB-PUB-121016-32
Date
2012
Source
Environmental science & technology   46(21): 11678-11683 (Journal)
Registered Authors
Cheng, Shuk Han
Keywords
none
MeSH Terms
  • Alpha Particles/adverse effects*
  • Animal Communication*
  • Animals
  • Apoptosis/radiation effects
  • Dose-Response Relationship, Radiation
  • Embryo, Nonmammalian/physiology
  • Hormesis/physiology*
  • Stress, Physiological/physiology*
  • Zebrafish/physiology*
PubMed
23050846 Full text @ Env. Sci. Tech.
Abstract

We report data showing that embryos of the zebrafish, Danio rerio, at 1.5 h post fertilization (hpf) subjected to a low-dose alpha-particle irradiation can release a stress signal into the water, which can be communicated to unirradiated bystander zebrafish embryos sharing the same water medium to induce a hormetic effect in the bystander embryos. Hormesis describes the phenomenon that low doses of a stressor drop the toxic effect to below the spontaneous level. The effects on the whole embryos were studied through quantification of apoptotic signals at 24 hpf through staining with the vital dye acridine orange, followed by counting the stained cells under a microscope. The results show that, for low alpha-particle dose, the number of apoptotic signals decreases in the irradiated embryos and also in the unirradiated bystander embryos having partnered with the irradiated embryos. These suggested that alpha-particle-irradiated zebrafish embryos could release a stress signal into the water, which could be communicated to unirradiated bystander zebrafish embryos sharing the same water medium to induce a hormetic effect in the bystander embryos.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping