Heart repair and regeneration: Recent insights from zebrafish studies
- Authors
- Lien, C.L., Harrison, M.R., Tuan, T.L., and Starnes, V.A.
- ID
- ZDB-PUB-120724-20
- Date
- 2012
- Source
- Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20(5): 638-646 (Review)
- Registered Authors
- Harrison, Michael, Lien, Ching-Ling (Ellen)
- Keywords
- none
- MeSH Terms
-
- Animals
- Cardiovascular Diseases/pathology
- Cardiovascular Diseases/physiopathology
- Cardiovascular Physiological Phenomena
- Cell Proliferation
- Endocardium/cytology
- Endocardium/physiology
- Heart/physiology*
- Heart/physiopathology
- Humans
- Models, Animal
- Myocardium/cytology
- Myocytes, Cardiac*/physiology
- Pericardium/cytology
- Pericardium/physiology
- Regeneration*
- Zebrafish*
- PubMed
- 22818295 Full text @ Wound Repair Regen.
Cardiovascular disease is the leading cause of death in the US and worldwide. Failure to properly repair or regenerate damaged cardiac tissues after myocardial infarction is a major cause of heart failure. In contrast to humans and other mammals, zebrafish hearts regenerate after substantial injury or tissue damage. Here, we review recent progress in studying zebrafish heart regeneration, addressing the molecular and cellular responses in the three tissue layers of the heart: myocardium, epicardium, and endocardium. We also compare different injury models utilized to study zebrafish heart regeneration and discuss the differences in responses to injury between mammalian and zebrafish hearts. By learning how zebrafish hearts regenerate naturally, we can better design therapeutic strategies for repairing human hearts after myocardial infarction.