PUBLICATION

Conserved Expression Signatures between Medaka and Human Pigment Cell Tumors

Authors
Schartl, M., Kneitz, S., Wilde, B., Wagner, T., Henkel, C.V., Spaink, H.P., and Meierjohann, S.
ID
ZDB-PUB-120630-7
Date
2012
Source
PLoS One   7(5): e37880 (Journal)
Registered Authors
Schartl, Manfred, Spaink, Herman P., Wagner, Toni
Keywords
none
MeSH Terms
  • Animals
  • Cell Line, Tumor
  • Humans
  • MAP Kinase Signaling System/genetics
  • Melanoma/genetics*
  • Melanoma/pathology
  • Oryzias/genetics*
  • Skin Neoplasms/genetics
  • Skin Neoplasms/pathology
  • Transcriptome*
  • Uveal Neoplasms/genetics
  • Uveal Neoplasms/pathology
PubMed
22693581 Full text @ PLoS One
Abstract

Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such relevant expression differences from the plethora of changes noted in global expression profiling studies, we searched for changes of gene expression levels that are conserved. Transcriptomes from massive parallel sequencing of different types of melanoma from medaka were generated and compared to microarray datasets from zebrafish and human melanoma. This revealed molecular conservation at various levels between fish models and human tumors providing a useful strategy for identifying expression signatures strongly associated with disease phenotypes and uncovering new melanoma molecules.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping