PUBLICATION

Zebrafish: A Model for Understanding Diabetic Complications

Authors
Jörgens, K., Hillebrands, J.L., Hammes, H.P., and Kroll, J.
ID
ZDB-PUB-120314-15
Date
2012
Source
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association   120(4): 186-187 (Review)
Registered Authors
Kroll, Jens
Keywords
cardiovascular incidences, cardiovascular risk management, zebrafish
MeSH Terms
  • Animals
  • Comprehension/physiology
  • Diabetes Complications/etiology*
  • Diabetes Complications/genetics
  • Diabetes Complications/pathology
  • Diabetes Complications/physiopathology
  • Disease Models, Animal*
  • Humans
  • Regeneration/genetics
  • Regeneration/physiology
  • Wound Healing/genetics
  • Wound Healing/physiology
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish/physiology*
PubMed
22402952 Full text @ Exp. Clin. Endocrinol. Diabetes
Abstract

Diabetes mellitus causes several vascular complications in patients, such as macrovascular problems including myocardial infarction, peripheral artery diseases and stroke and microvascular problems including nephropathy and retinopathy. Likewise, diabetes mellitus is associated with other complications such as neuropathy and delayed wound healing. The zebrafish has been used for decades as a model organism for studies in developmental biology. In fact several common and important developmental mechanisms have been identified in zebrafish which are similar in mammals. The zebrafish has short generation intervals and zebrafish embryos are transparent and therefore provide unique imaging opportunities. In combination with genetic manipulations, including gene silencing protocols by using morpholinos, mutant or transgenic fish lines, the zebrafish has become one of the most important models in developmental biology. Over and above, zebrafish is also an established model organism for several pathophysiological conditions which are related to human diseases. For instance, zebrafish is used as an inflammation and regeneration model because of its ability to partially compensate for organ loss (e. g., heart and fins). It is also used for drug screening, in tumor biology, for systems biology, congenital and hereditary disease, and in infection 1.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping