PUBLICATION
Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods
- Authors
- Patra, C.R., Kim, J.H., Pramanik, K., d'Uscio, L.V., Patra, S., Pal, K., Ramchandran, R., Strano, M.S., and Mukhopadhyay, D.
- ID
- ZDB-PUB-111021-4
- Date
- 2011
- Source
- Nano Letters 11(11): 4932-8 (Journal)
- Registered Authors
- Ramchandran, Ramani
- Keywords
- Europium hydroxide [EuIII(OH)3] nanorods; reactive oxygen species; hydrogen peroxide (H2O2); single-walled carbon nanotubes; in vivo angiogenesis; zebrafish model
- MeSH Terms
-
- Cells, Cultured
- Endothelial Cells/drug effects*
- Endothelial Cells/physiology*
- Humans
- Inorganic Chemicals/pharmacology*
- Nanoparticles/administration & dosage*
- Neovascularization, Physiologic/drug effects*
- Neovascularization, Physiologic/physiology*
- Reactive Oxygen Species/metabolism*
- PubMed
- 21967244 Full text @ Nano Lett.
Citation
Patra, C.R., Kim, J.H., Pramanik, K., d'Uscio, L.V., Patra, S., Pal, K., Ramchandran, R., Strano, M.S., and Mukhopadhyay, D. (2011) Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods. Nano Letters. 11(11):4932-8.
Abstract
The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O2·) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·– from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping