PUBLICATION
Collective cell migration guided by dynamically maintained gradients
- Authors
- Streichan, S.J., Valentin, G., Gilmour, D., and Hufnagel, L.
- ID
- ZDB-PUB-110719-7
- Date
- 2011
- Source
- Physical Biology 8(4): 045004 (Journal)
- Registered Authors
- Gilmour, Darren
- Keywords
- none
- MeSH Terms
-
- Algorithms
- Animals
- Chemotactic Factors/genetics
- Chemotactic Factors/metabolism
- Chemotaxis*
- Gene Expression Regulation, Developmental
- Models, Biological*
- Organogenesis
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 21750360 Full text @ Phys. Biol.
Citation
Streichan, S.J., Valentin, G., Gilmour, D., and Hufnagel, L. (2011) Collective cell migration guided by dynamically maintained gradients. Physical Biology. 8(4):045004.
Abstract
How cell collectives move and deposit subunits within a developing embryo is a question of outstanding interest. In many cases, a chemotactic mechanism is employed, where cells move up or down a previously generated attractive or repulsive gradient of signalling molecules. Recent studies revealed the existence of systems with isotropic chemoattractant expression in the lateral line primordium of zebrafish. Here we propose a mechanism for a cell collective, which actively modulates an isotropically expressed ligand and encodes an initial symmetry breaking in its velocity. We derive a closed solution for the velocity and identify an optimal length that maximizes the tissues' velocity. A length dependent polar gradient is identified, its use for pro-neuromast deposition is shown by simulations and a critical time for cell deposition is derived. Experiments to verify this model are suggested.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping