PUBLICATION

Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in

Authors
van der Velden, Y.U., and Haramis, A.P.
ID
ZDB-PUB-110706-7
Date
2011
Source
Aging   3(4): 363-367 (Review)
Registered Authors
Haramis, Anna-Pavlina
Keywords
none
MeSH Terms
  • Animals
  • Cell Polarity
  • Energy Metabolism
  • Humans
  • Peutz-Jeghers Syndrome/pathology
  • Peutz-Jeghers Syndrome/physiopathology
  • Protein Serine-Threonine Kinases/genetics
  • Protein Serine-Threonine Kinases/metabolism*
  • Signal Transduction/physiology
  • Tumor Suppressor Proteins/genetics
  • Tumor Suppressor Proteins/metabolism*
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed
21721170 Full text @ Aging (Albany NY)
Abstract
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy-metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue-specific and context-dependent effectors.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping