PUBLICATION
Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in
- Authors
- van der Velden, Y.U., and Haramis, A.P.
- ID
- ZDB-PUB-110706-7
- Date
- 2011
- Source
- Aging 3(4): 363-367 (Review)
- Registered Authors
- Haramis, Anna-Pavlina
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Polarity
- Energy Metabolism
- Humans
- Peutz-Jeghers Syndrome/pathology
- Peutz-Jeghers Syndrome/physiopathology
- Protein Serine-Threonine Kinases/genetics
- Protein Serine-Threonine Kinases/metabolism*
- Signal Transduction/physiology
- Tumor Suppressor Proteins/genetics
- Tumor Suppressor Proteins/metabolism*
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 21721170 Full text @ Aging (Albany NY)
Citation
van der Velden, Y.U., and Haramis, A.P. (2011) Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in. Aging. 3(4):363-367.
Abstract
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy-metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue-specific and context-dependent effectors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping