PUBLICATION

One step forward: The use of transgenic zebrafish tumor model in drug screens

Authors
Huang, X., Nguyen, A.T., Li, Z., Emelyanov, A., Parinov, S., and Gong, Z.
ID
ZDB-PUB-110628-24
Date
2011
Source
Birth defects research. Part C, Embryo today : reviews   93(2): 173-181 (Review)
Registered Authors
Gong, Zhiyuan, Li, Zhen, Parinov, Serguei
Keywords
zebrafish, drug screening, liver cancer, transgenic fish
MeSH Terms
  • Animals
  • Animals, Genetically Modified*
  • Drug Discovery/methods*
  • Drug Screening Assays, Antitumor/methods*
  • Gene Expression Regulation, Neoplastic/genetics
  • Gene Expression Regulation, Neoplastic/physiology*
  • Liver Neoplasms/drug therapy*
  • Liver Neoplasms/genetics
  • Liver Neoplasms/physiopathology
  • Models, Animal*
  • Signal Transduction/genetics
  • Signal Transduction/physiology*
  • Zebrafish*
PubMed
21671356 Full text @ Birth Defects Res. C Embryo Today
Abstract
The zebrafish (Danio rerio) has been an experimental model in the developmental biology and toxicology since the 1950s. In recent years, with the aid of transgenic technology, it has also gained an increasing popularity to model human diseases, including various cancers. As a feasible vertebrate model for large-scale chemical screens, the zebrafish has also given us a new option for the search of potential anticancer drugs. It is hopeful that in the near future with automation and analytical tools, drug development processes will be significantly shortened for quick and effective identification of candidate drugs.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping