PUBLICATION
Effects of piracetam on behavior and memory in adult zebrafish
- Authors
- Grossman, L., Stewart, A., Gaikwad, S., Utterback, E., Wu, N., Dileo, J., Frank, K., Hart, P., Howard, H., and Kalueff, A.V.
- ID
- ZDB-PUB-110317-21
- Date
- 2011
- Source
- Brain research bulletin 85(1-2): 58-63 (Journal)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Piracetam, Anxiolytic action, Zebrafish, Behavioral testing, Memory, Nootropic effects
- MeSH Terms
-
- Animals
- Behavior, Animal/drug effects*
- Female
- Humans
- Male
- Maze Learning/drug effects
- Memory/drug effects*
- Nootropic Agents/pharmacology*
- Piracetam/pharmacology*
- Zebrafish/physiology*
- PubMed
- 21371538 Full text @ Brain Res. Bull.
Citation
Grossman, L., Stewart, A., Gaikwad, S., Utterback, E., Wu, N., Dileo, J., Frank, K., Hart, P., Howard, H., and Kalueff, A.V. (2011) Effects of piracetam on behavior and memory in adult zebrafish. Brain research bulletin. 85(1-2):58-63.
Abstract
Piracetam, a derivative of γ-aminobutyric acid, exerts memory-enhancing and mild anxiolytic effects in human and rodent studies. To examine the drug's behavioral profile further, we assessed its effects on behavioral and endocrine (cortisol) responses of adult zebrafish (Danio rerio) - a novel model species rapidly gaining popularity in neurobehavioral research. Overall, acute piracetam did not affect zebrafish novel tank and light-dark box behavior at mild doses (25-400mg/L), but produced nonspecific behavioral inhibition at 700mg/L. No effects on cortisol levels or inter-/intra-session habituation in the novel tank test were observed for acute or chronic mild non-sedative dose of 200mg/L. In contrast, fish exposed to chronic piracetam at this dose performed significantly better in the cued learning plus-maze test. This observation parallels clinical and rodent literature on the behavioral profile of piracetam, supporting the utility of zebrafish paradigms for testing nootropic agents.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping