PUBLICATION

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Authors
Stewart, A., Wu, N., Cachat, J., Hart, P., Gaikwad, S., Wong, K., Utterback, E., Gilder, T., Kyzar, E., Newman, A., Carlos, D., Chang, K., Hook, M., Rhymes, C., Caffery, M., Greenberg, M., Zadina, J., and Kalueff, A.V.
ID
ZDB-PUB-101209-6
Date
2011
Source
Progress in neuro-psychopharmacology & biological psychiatry   35(6): 1421-1431 (Review)
Registered Authors
Cachat, Jonathan, Kalueff, Allan V.
Keywords
Anxiety, Anxiolytic drugs, Anxiogenic drugs, Novelty-based paradigms, Novel tank test, Stress, Zebrafish
MeSH Terms
  • Animals
  • Anti-Anxiety Agents/pharmacology*
  • Anti-Anxiety Agents/therapeutic use*
  • Anxiety/chemically induced
  • Anxiety/drug therapy*
  • Disease Models, Animal*
  • Exploratory Behavior/drug effects
  • Humans
  • Phenotype
  • Synaptic Transmission/drug effects*
  • Zebrafish
PubMed
21122812 Full text @ Prog. Neuropsychopharmacol. Biol. Psychiatry
Abstract
Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping