PUBLICATION

Perspectives on endocrine disruptor effects on metabolic sensors

Authors
Migliarini, B., Piccinetti, C.C., Martella, A., Maradonna, F., Gioacchini, G., and Carnevali, O.
ID
ZDB-PUB-101209-22
Date
2011
Source
General and comparative endocrinology   170(3): 416-423 (Review)
Registered Authors
Carnevali, Oliana
Keywords
EDs, body weight, food intake, lipid metabolism
MeSH Terms
  • Animals
  • Body Weight/drug effects
  • Diethylhexyl Phthalate/toxicity
  • Eating/drug effects
  • Endocrine Disruptors/toxicity*
  • Hormones/metabolism
  • Hypothalamus/drug effects
  • Hypothalamus/physiology
  • Lipid Metabolism/drug effects
  • Metabolic Diseases/etiology
  • Metabolic Diseases/metabolism
  • Receptors, Cell Surface/drug effects*
  • Steroids/metabolism
  • Zebrafish
PubMed
21130769 Full text @ Gen. Comp. Endocrinol.
Abstract
Endocrine disrupting chemicals (EDs) can increase or block the metabolism of endogenous peptidergic or steroid hormones by activating or antagonizing nuclear receptors in the hypothalamus, besides adipose tissue, liver and gonads. Toxicological and epidemiological studies have suggested the involvement of different EDs in an increasing number of metabolic disorders such as obesity and diabetes. The aim of this review is to summarize the literature from experimental animal studies demonstrating the impairment of body weight raised by the deregulation of peptidergic signals as well as by the activation of key metabolic molecular targets. Regarding the modification of gene transcription levels induced by EDs, new data on DEHP effect on food intake and lipid metabolism in the experimental model zebrafish (Danio rerio) have also been includedin this review providing evidences about the dangerousness of DEHPlow doses.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping