PUBLICATION
Parallel visual cycles in the zebrafish retina
- Authors
- Fleisch, V.C., and Neuhauss, S.C.
- ID
- ZDB-PUB-100525-13
- Date
- 2010
- Source
- Progress in Retinal and Eye Research 29(6): 476-486 (Review)
- Registered Authors
- Fleisch, Valerie, Neuhauss, Stephan
- Keywords
- none
- MeSH Terms
-
- Animals
- Models, Animal
- Neuroglia/physiology
- Retina/cytology
- Retina/physiology*
- Retinal Cone Photoreceptor Cells/metabolism
- Retinal Cone Photoreceptor Cells/physiology*
- Retinaldehyde/metabolism
- Vision, Ocular/physiology*
- Visual Pathways/anatomy & histology
- Visual Pathways/physiology
- Zebrafish/anatomy & histology*
- PubMed
- 20488254 Full text @ Prog. Retin. Eye Res.
Citation
Fleisch, V.C., and Neuhauss, S.C. (2010) Parallel visual cycles in the zebrafish retina. Progress in Retinal and Eye Research. 29(6):476-486.
Abstract
Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping