PUBLICATION
Calcium signaling in vertebrate embryonic patterning and morphogenesis
- Authors
- Slusarski, D.C., and Pelegri, F.
- ID
- ZDB-PUB-090422-4
- Date
- 2007
- Source
- Developmental Biology 307(1): 1-13 (Review)
- Registered Authors
- Pelegri, Francisco, Slusarski, Diane C.
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning*
- Calcium Signaling/physiology*
- Humans
- Morphogenesis*
- Organizers, Embryonic/cytology
- Stem Cells/cytology
- Stem Cells/physiology
- Vertebrates
- Wnt Proteins/metabolism
- PubMed
- 17531967 Full text @ Dev. Biol.
Citation
Slusarski, D.C., and Pelegri, F. (2007) Calcium signaling in vertebrate embryonic patterning and morphogenesis. Developmental Biology. 307(1):1-13.
Abstract
Signaling pathways that rely on the controlled release and/or accumulation of calcium ions are important in a variety of developmental events in the vertebrate embryo, affecting cell fate specification and morphogenesis. One such major developmentally important pathway is the Wnt/calcium signaling pathway, which, through its antagonism of Wnt/beta-catenin signaling, appears to regulate the formation of the early embryonic organizer. In addition, the Wnt/calcium pathway shares components with another non-canonical Wnt pathway involved in planar cell polarity, suggesting that these two pathways form a loose network involved in polarized cell migratory movements that fashion the vertebrate body plan. Furthermore, left-right axis determination, neural induction and somite formation also display dynamic calcium release, which may be critical in these patterning events. Finally, we summarize recent evidence that propose a role for calcium signaling in stem cell biology and human developmental disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping