PUBLICATION

Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes

Authors
Cooper, C.D., and Raible, D.W.
ID
ZDB-PUB-081028-3
Date
2009
Source
Seminars in cell & developmental biology   20(1): 105-110 (Review)
Registered Authors
Raible, David
Keywords
melanocytes, differentiation, neural crest, specification
MeSH Terms
  • Animals
  • Cell Differentiation*
  • Humans
  • Melanocytes/cytology*
  • Neural Crest/cytology*
  • Sensitivity and Specificity
PubMed
18935965 Full text @ Sem. Cell Dev. Biol.
Abstract
Black pigment cells, or melanocytes, are the major contributing cells to pigmentation in vertebrate organisms. Although the function of these cells is distinct depending on the organism, the events involved in their development are remarkably similar. Here, we review the mechanisms involved in the early development of melanocytes from neural crest, many of which are conserved in organisms as diverse as zebrafish, birds and humans. We also discuss recent studies that provide further insight into how melanocyte differentiation is achieved and maintained.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping