PUBLICATION
cneViewer: A Database of Conserved Non-coding Elements for Studies of Tissue-Specific Gene Regulation
- Authors
- Persampieri, J., Ritter, D.I., Lees, D., Lehoczky, J., Li, Q., Guo, S., and Chuang, J.H.
- ID
- ZDB-PUB-080826-42
- Date
- 2008
- Source
- Bioinformatics (Oxford, England) 24(20): 2418-2419 (Journal)
- Registered Authors
- Guo, Su, Li, Qiang
- Keywords
- none
- MeSH Terms
-
- Animals
- Base Sequence
- Computational Biology/methods*
- Conserved Sequence
- DNA/chemistry
- Databases, Genetic*
- Gene Expression Regulation*
- Humans
- Internet
- Molecular Sequence Data
- Regulatory Sequences, Nucleic Acid*
- Software
- Zebrafish/genetics*
- PubMed
- 18718943 Full text @ Bioinformatics
Citation
Persampieri, J., Ritter, D.I., Lees, D., Lehoczky, J., Li, Q., Guo, S., and Chuang, J.H. (2008) cneViewer: A Database of Conserved Non-coding Elements for Studies of Tissue-Specific Gene Regulation. Bioinformatics (Oxford, England). 24(20):2418-2419.
Abstract
There are thousands of strongly conserved noncoding elements (CNEs) in vertebrate genomes, and their functions remain largely unknown. However, without biologically relevant criteria for prioritizing them, selecting particular CNE sequences to study can be haphazard. To address this problem, we present cneViewer - a database and webtool that systematizes information on conserved non-coding DNA elements in zebrafish. A key feature is the ability to search for CNEs that may be relevant to tissue-specific gene regulation, based on known developmental expression patterns of nearby genes. cneViewer provides this and other organizing features that significantly facilitate experimental design and CNE analysis. AVAILABILITY: http://cneviewer.zebrafishcne.org.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping