PUBLICATION

Erythropoietins from teleosts

Authors
Chu, C.Y., Cheng, C.H., Yang, C.H., and Huang, C.J.
ID
ZDB-PUB-080722-5
Date
2008
Source
Cellular and molecular life sciences : CMLS   65(22): 3545-3552 (Review)
Registered Authors
Huang, Chang-Jen
Keywords
EPO, EPO receptor, glycosylation, secretion, zebrafish
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Erythropoietin/genetics*
  • Erythropoietin/metabolism*
  • Fishes/genetics*
  • Fishes/metabolism
  • Fishes/physiology
  • Gene Components
  • Janus Kinases/metabolism
  • Kidney/metabolism
  • Molecular Sequence Data
  • STAT Transcription Factors/metabolism
  • Signal Transduction/physiology*
PubMed
18622577 Full text @ Cell. Mol. Life Sci.
Abstract
The epo genes of many teleosts, including zebrafish, have been cloned following the first identification of nonmammalian EPO from fugu in 2004. The zebrafish (Danio rerio) animal model is well suited for both developmental and genetic analyses for studying vertebrate erythropoiesis. The purpose of this review is to provide an update of recent progress in research on teleost EPO with a focus on its structure, expression and secretion. The EPO receptor and the downstream JAK/STAT signaling pathway are also discussed.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping