PUBLICATION

Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery

Authors
Crawford, A.D., Esguerra, C.V., and de Witte, P.A.
ID
ZDB-PUB-080630-21
Date
2008
Source
Planta Medica   74(6): 624-632 (Review)
Registered Authors
Crawford, Alexander, Esguerra, Camila V.
Keywords
zebrafish, Danio rerio, bioassay-guided fractionation, chemical genetics, in vivo drug discovery
MeSH Terms
  • Animals
  • Biological Assay*
  • Biological Products/pharmacology*
  • Humans
  • Models, Animal*
  • Zebrafish*
PubMed
18584811 Full text @ Planta Med.
Abstract
Emerging challenges within the current drug discovery paradigm are prompting renewed interest in natural products as a source of novel, bioactive small molecules. With the recent validation of zebrafish as a biomedically relevant model for functional genomics and in vivo drug discovery, the zebrafish bioassay-guided identification of natural products may be an attractive strategy to generate new lead compounds in a number of indication areas. Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping