PUBLICATION
Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery
- Authors
- Crawford, A.D., Esguerra, C.V., and de Witte, P.A.
- ID
- ZDB-PUB-080630-21
- Date
- 2008
- Source
- Planta Medica 74(6): 624-632 (Review)
- Registered Authors
- Crawford, Alexander, Esguerra, Camila V.
- Keywords
- zebrafish, Danio rerio, bioassay-guided fractionation, chemical genetics, in vivo drug discovery
- MeSH Terms
-
- Animals
- Biological Assay*
- Biological Products/pharmacology*
- Humans
- Models, Animal*
- Zebrafish*
- PubMed
- 18584811 Full text @ Planta Med.
Citation
Crawford, A.D., Esguerra, C.V., and de Witte, P.A. (2008) Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery. Planta Medica. 74(6):624-632.
Abstract
Emerging challenges within the current drug discovery paradigm are prompting renewed interest in natural products as a source of novel, bioactive small molecules. With the recent validation of zebrafish as a biomedically relevant model for functional genomics and in vivo drug discovery, the zebrafish bioassay-guided identification of natural products may be an attractive strategy to generate new lead compounds in a number of indication areas. Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping