PUBLICATION
Ca(2+) Signalling and early embryonic patterning during zebrafish development
- Authors
- Webb, S.E., and Miller, A.L.
- ID
- ZDB-PUB-070806-5
- Date
- 2007
- Source
- Clinical and experimental pharmacology & physiology 34(9): 897-904 (Review)
- Registered Authors
- Miller, Andrew L., Webb, Sarah E.
- Keywords
- none
- MeSH Terms
-
- Animals
- Blastula/metabolism
- Body Patterning*
- Calcium Signaling*
- Cell Movement
- Cleavage Stage, Ovum/metabolism
- Cytokinesis
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/metabolism
- Embryonic Stem Cells/metabolism*
- Gastrula/metabolism
- Time Factors
- Zebrafish/embryology*
- Zebrafish/metabolism
- PubMed
- 17645637 Full text @ Clin. Exp. Pharmacol. Physiol.
Citation
Webb, S.E., and Miller, A.L. (2007) Ca(2+) Signalling and early embryonic patterning during zebrafish development. Clinical and experimental pharmacology & physiology. 34(9):897-904.
Abstract
1. It has been proposed that Ca(2+) signalling, in the form of pulses, waves and steady gradients, may play a crucial role in key pattern-forming events during early vertebrate development. 2. With reference to the embryo of the zebrafish (Danio rerio), herein we review the Ca(2+) transients reported from the cleavage to segmentation periods. This time-window includes most of the major pattern-forming events of early development, which transform a single-cell zygote into a complex multicellular embryo with established primary germ layers and body axes. 3. Data are presented to support our proposal that intracellular Ca(2+) waves are an essential feature of embryonic cytokinesis and that propagating intercellular Ca(2+) waves (both long and short range) may play a crucial role in: (i) the establishment of the embryonic periderm and the coordination of cell movements during epiboly, convergence and extension; (ii) the establishment of the basic embryonic axes and germ layers; and (iii) definition of the morphological boundaries of specific tissue domains and embryonic structures, including future organ anlagen. 4. The potential downstream targets of these Ca(2+) transients are also discussed, as well as how they may integrate with other pattern-forming signalling pathways known to modulate early developmental events.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping