PUBLICATION

Ca(2+) Signalling and early embryonic patterning during zebrafish development

Authors
Webb, S.E., and Miller, A.L.
ID
ZDB-PUB-070806-5
Date
2007
Source
Clinical and experimental pharmacology & physiology   34(9): 897-904 (Review)
Registered Authors
Miller, Andrew L., Webb, Sarah E.
Keywords
none
MeSH Terms
  • Animals
  • Blastula/metabolism
  • Body Patterning*
  • Calcium Signaling*
  • Cell Movement
  • Cleavage Stage, Ovum/metabolism
  • Cytokinesis
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism
  • Embryonic Stem Cells/metabolism*
  • Gastrula/metabolism
  • Time Factors
  • Zebrafish/embryology*
  • Zebrafish/metabolism
PubMed
17645637 Full text @ Clin. Exp. Pharmacol. Physiol.
Abstract
1. It has been proposed that Ca(2+) signalling, in the form of pulses, waves and steady gradients, may play a crucial role in key pattern-forming events during early vertebrate development. 2. With reference to the embryo of the zebrafish (Danio rerio), herein we review the Ca(2+) transients reported from the cleavage to segmentation periods. This time-window includes most of the major pattern-forming events of early development, which transform a single-cell zygote into a complex multicellular embryo with established primary germ layers and body axes. 3. Data are presented to support our proposal that intracellular Ca(2+) waves are an essential feature of embryonic cytokinesis and that propagating intercellular Ca(2+) waves (both long and short range) may play a crucial role in: (i) the establishment of the embryonic periderm and the coordination of cell movements during epiboly, convergence and extension; (ii) the establishment of the basic embryonic axes and germ layers; and (iii) definition of the morphological boundaries of specific tissue domains and embryonic structures, including future organ anlagen. 4. The potential downstream targets of these Ca(2+) transients are also discussed, as well as how they may integrate with other pattern-forming signalling pathways known to modulate early developmental events.
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