PUBLICATION
Zebrafish Gastrulation: Cell Movements, Signals, and Mechanisms
- Authors
- Rohde, L.A., and Heisenberg, C.P.
- ID
- ZDB-PUB-070625-22
- Date
- 2007
- Source
- International review of cytology 261C: 159-192 (Review)
- Registered Authors
- Heisenberg, Carl-Philipp, Rohde, Laurel
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Adhesion
- Cell Movement/physiology*
- Embryo, Nonmammalian/physiology
- Extracellular Matrix/metabolism
- Gastrula/physiology
- Signal Transduction*
- Wnt Proteins/metabolism
- Zebrafish/embryology*
- Zebrafish/physiology
- PubMed
- 17560282 Full text @ Int. Rev. Cytol.
Citation
Rohde, L.A., and Heisenberg, C.P. (2007) Zebrafish Gastrulation: Cell Movements, Signals, and Mechanisms. International review of cytology. 261C:159-192.
Abstract
Gastrulation is a morphogenetic process that results in the formation of the embryonic germ layers. Here we detail the major cell movements that occur during zebrafish gastrulation: epiboly, internalization, and convergent extension. Although gastrulation is known to be regulated by signaling pathways such as the Wnt/planar cell polarity pathway, many questions remain about the underlying molecular and cellular mechanisms. Key factors that may play a role in gastrulation cell movements are cell adhesion and cytoskeletal rearrangement. In addition, some of the driving force for gastrulation may derive from tissue interactions such as those described between the enveloping layer and the yolk syncytial layer. Future exploration of gastrulation mechanisms relies on the development of sensitive and quantitative techniques to characterize embryonic germ-layer properties.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping