PUBLICATION

Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously

Authors
Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M.
ID
ZDB-PUB-061020-3
Date
2006
Source
Development (Cambridge, England)   133(8): 1433-1443 (Journal)
Registered Authors
Hibi, Masahiko, Hirata, Tsutomu, Nakazawa, Masato, Yoshihara, Yoshihiro
Keywords
Fez, Zinc finger, Olfactory sensory neuron, Olfactory bulb, Axon guidance, Mitral cell, Interneuron, Rostral migratory stream, Mouse
MeSH Terms
  • Animals
  • Axonal Transport/genetics
  • Cell Differentiation/genetics
  • Cell Movement/genetics
  • Crosses, Genetic
  • DNA-Binding Proteins/biosynthesis
  • DNA-Binding Proteins/deficiency
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/physiology
  • Female
  • Interneurons/cytology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Molecular Sequence Data
  • Nerve Tissue Proteins/biosynthesis
  • Nerve Tissue Proteins/deficiency
  • Nerve Tissue Proteins/genetics*
  • Nerve Tissue Proteins/physiology
  • Neurons, Afferent/cytology
  • Neurons, Afferent/metabolism*
  • Neurons, Afferent/physiology*
  • Olfactory Bulb/cytology
  • Olfactory Bulb/embryology*
  • Signal Transduction/genetics
  • Stem Cells/metabolism
  • Zinc Fingers/genetics*
PubMed
16540508 Full text @ Development
Abstract
Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. To reveal its function, we generated Fez-deficient mice. The Fez-deficient mice showed several abnormalities in the olfactory system: (1) impaired axonal projection of the olfactory sensory neurons; (2) reduced size of the olfactory bulb; (3) abnormal layer formation in the olfactory bulb; and (4) aberrant rostral migration of the interneuron progenitors. Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping