PUBLICATION

Mesoderm induction: from caps to chips

Authors
Kimelman, D.
ID
ZDB-PUB-060419-10
Date
2006
Source
Nature reviews. Genetics   7(5): 360-372 (Review)
Registered Authors
Kimelman, David
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning
  • Chickens/metabolism
  • Embryonic Induction*
  • Gene Expression Regulation, Developmental*
  • Glycoproteins/metabolism
  • Membrane Proteins/metabolism
  • Mesoderm/cytology
  • Mesoderm/metabolism*
  • Mice
  • Models, Biological
  • Signal Transduction
  • Transforming Growth Factor beta/metabolism
  • Wnt Proteins/metabolism
  • Xenopus/embryology
  • Xenopus/metabolism
  • Xenopus Proteins
  • Zebrafish/embryology
  • Zebrafish/metabolism
  • Zebrafish Proteins/metabolism
PubMed
16619051 Full text @ Nat. Rev. Genet.
Abstract
Vertebrate mesoderm induction is one of the classical problems in developmental biology. Various developmental biology approaches, particularly in Xenopus and zebrafish, have identified many of the key factors that are involved in this process and have provided major insights into how these factors interact as part of a signalling and transcription-factor network. These data are beginning to be refined by high-throughput approaches such as microarray assays. Future challenges include understanding how the prospective mesodermal cells integrate the various signals they receive and how they resolve this information to regulate their morphogenetic behaviours and cell-fate decisions.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping