PUBLICATION

Ontogenesis of oxygen chemoreception in aquatic vertebrates

Authors
Jonz, M.G., and Nurse, C.A.
ID
ZDB-PUB-060302-10
Date
2006
Source
Respiratory Physiology & Neurobiology   154(1-2): 139-152 (Journal)
Registered Authors
Jonz, Michael G.
Keywords
Development, Oxygen sensing, Chemoreceptors, NEC, Hypoxia, Gills, Evolution, Fish, Amphibians
MeSH Terms
  • Amphibians/physiology*
  • Animals
  • Behavior, Animal
  • Chemoreceptor Cells/physiology*
  • Fishes/physiology*
  • Gills/embryology
  • Gills/growth & development
  • Gills/physiology
  • Oxygen/metabolism*
  • Pulmonary Gas Exchange/physiology
  • Respiratory Physiological Phenomena*
PubMed
16488670 Full text @ Respir. Physiol. Neurobiol.
Abstract
In aquatic vertebrates, peripheral O(2) chemoreceptors initiate compensatory physiological and behavioural responses to hypoxia, beginning at very early stages of development, to maintain sufficient gas exchange across the skin or gills. This review highlights the morphological and physiological studies, particularly those of zebrafish, that have contributed to the current understanding of the development of O(2) chemoreception and the response to hypoxic challenges in embryonic and larval stages of fish and amphibians. The gills appear to be the primary site of O(2) chemoreception in developing aquatic vertebrates and initiate ventilatory changes, and adult-like O(2)-sensitive neuroepithelial cells (NECs) are found in the gills in larval stages of zebrafish and Xenopus laevis. However, evidence from zebrafish studies indicates that extrabranchial O(2) chemoreceptors appear before gill NECs and regulate responses to hypoxia that develop earlier. The developmental and evolutionary significance of the internal migration of O(2)-chemoreceptive sites with changes in respiratory organs is also discussed.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping