PUBLICATION
Zebrafish Cell Clocks Feel the Heat and See the Light!
- Authors
- Vallone, D., Lahiri, K., Dickmeis, T., and Foulkes, N.S.
- ID
- ZDB-PUB-051221-10
- Date
- 2005
- Source
- Zebrafish 2(3): 171-187 (Review)
- Registered Authors
- Dickmeis, Thomas, Foulkes, Nicholas-Simon, Lahiri, Kajori, Vallone, Daniela
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 18248192 Full text @ Zebrafish
Citation
Vallone, D., Lahiri, K., Dickmeis, T., and Foulkes, N.S. (2005) Zebrafish Cell Clocks Feel the Heat and See the Light!. Zebrafish. 2(3):171-187.
Abstract
The zebrafish has rapidly become established as one of the most valuable vertebrate models for studying circadian clock function. A major initial attraction was its utility in large-scale genetic screens. It subsequently emerged that most zebrafish cells possess circadian clocks that can be entrained directly by exposure to temperature or light dark cycles, a property shared by several zebrafish cell lines. This is not the case for mammals, where the retina is the primary source of light input to the clock. Furthermore, mammalian cell culture clocks can only be entrained by acute culture treatments such as serum shocks. Thus, the zebrafish is proving invaluable to study light and temperature input to the vertebrate clock. In addition, the accessibility of its early developmental stages has placed the zebrafish at the forefront of studies aimed at understanding how the circadian clock is established during embryogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping