PUBLICATION
Zebrafish developmental genetics and central nervous system development
- Authors
- Blader, P. and Strähle, U.
- ID
- ZDB-PUB-000505-19
- Date
- 2000
- Source
- Human molecular genetics 9(6): 945-951 (Journal)
- Registered Authors
- Blader, Patrick, Strähle, Uwe
- Keywords
- none
- MeSH Terms
-
- Animals
- Central Nervous System/embryology*
- Zebrafish/embryology
- Zebrafish/genetics*
- PubMed
- 10767318 Full text @ Hum. Mol. Genet.
Citation
Blader, P. and Strähle, U. (2000) Zebrafish developmental genetics and central nervous system development. Human molecular genetics. 9(6):945-951.
Abstract
The central nervous system (CNS) is the most complex tissue of vertebrates. Recently, the zebrafish has emerged as a powerful genetic system for studying early development, and large-scale mutagenic screens for embryonic patterning defects have been accomplished. Mutants isolated in these screens are proving helpful in unravelling the mole-cular hierarchies involved in the development of the CNS. We review here recent studies in zebrafish which shed light on the genetic pathways involved in induction and regionalization of the CNS.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping