FIGURE

Fig. 6

ID
ZDB-FIG-180817-21
Publication
Lee et al., 2018 - Isobavachalcone from Angelica keiskei Inhibits Adipogenesis and Prevents Lipid Accumulation.
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Fig. 6

The anti-obesity effect of IBC in high fat cholesterol (HFC)-diet zebrafish. (A) Lateral view of 10 dpf larvae staining with ORO. Hepatic lipid accumulation was detected from HFC, and significant reduction of ORO staining was present in the liver with 100 nM IBC treatment (n = 75 each, * p < 0.01); (B) Representative images of live 10 dpf larvae following ingestion of NBD cholesterol (green-colored). Larvae with HFC showed high intensity in the gall bladder and intestine whereas larvae with the high fat cholesterol and 100 nM IBC treatment had reduced metabolism of NBD-cholesterol (n = 45 each, * p < 0.001); (C) Zebrafish total proteins were analyzed for C/EBPα expression. Data represent the mean ± SEM from 3 experiments (n = 30 each, * p < 0.01); and (D) Zebrafish total RNA was analyzed for C/EBPα and PPARγ expression. Data represent the mean ± SEM from 3 experiments (n = 30 each, * p < 0.05). Control, normal diet fed larvae; HFC, high fat cholesterol fed larvae; HFC + IBC, high fat cholesterol fed larvae with 100 nM IBC treatment.

Expression Data
Genes:
Fish:
Conditions:
Anatomical Term:
Stage: Days 7-13

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Observed In:
Stage: Days 7-13

Phenotype Detail
Acknowledgments
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