ZFIN Lab: Cellerino Lab

ZFIN ID: ZDB-LAB-180420-2

ZFIN ID: ZDB-LAB-180420-2

Cellerino Lab

PI/Director:	Cellerino, Alessandro
Contact Person:	Cellerino, Alessandro
Email:	alessandro.cellerino@sns.it
URL:	http://laboratoriobiologia.sns.it/alessandro-cellerino/
Address:	BIO@SNS c/o Istituto di Biofisica del CNR via Moruzzi 1 56124 Pisa
Country:	Italy
Phone:	+39-050-3152756
Fax:	+39-050-3152760
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Current research is focused on the biological mechanisms of aging using the shortest-lived vertebrate, the annual fish Nothobranchius furzeri that we developed as model organism for aging research and also zebrafish.

We integrate in a data-driven approach the genomic, molecular, cellular and organism levels of analysis to identify the physiological mechanisms controlling brain aging and lifespan

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Brogi, L., Marchese, M., Cellerino, A., Licitra, R., Naef, V., Mero, S., Bibbiani, C., Fronte, B. (2021) β-Glucans as Dietary Supplement to Improve Locomotion and Mitochondrial Respiration in a Model of Duchenne Muscular Dystrophy. Nutrients. 13(5):

Aramillo Irizar, P., Schäuble, S., Esser, D., Groth, M., Frahm, C., Priebe, S., Baumgart, M., Hartmann, N., Marthandan, S., Menzel, U., Müller, J., Schmidt, S., Ast, V., Caliebe, A., König, R., Krawczak, M., Ristow, M., Schuster, S., Cellerino, A., Diekmann, S., Englert, C., Hemmerich, P., Sühnel, J., Guthke, R., Witte, O.W., Platzer, M., Ruppin, E., Kaleta, C. (2018) Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly. Nature communications. 9:327

Heid, J., Cencioni, C., Ripa, R., Baumgart, M., Atlante, S., Milano, G., Scopece, A., Kuenne, C., Guenther, S., Azzimato, V., Farsetti, A., Rossi, G., Braun, T., Pompilio, G., Martelli, F., Zeiher, A.M., Cellerino, A., Gaetano, C., Spallotta, F. (2017) Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Scientific Reports. 7:16839

Baumgart, M., Barth, E., Savino, A., Groth, M., Koch, P., Petzold, A., Arisi, I., Platzer, M., Marz, M., Cellerino, A. (2017) A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri. BMC Genomics. 18:693

Ripa, R., Dolfi, L., Terrigno, M., Pandolfini, L., Savino, A., Arcucci, V., Groth, M., Terzibasi Tozzini, E., Baumgart, M., Cellerino, A. (2017) MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biology. 15:9

Baumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., Guthke, R., Platzer, M., Cellerino, A. (2016) Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell systems. 2:122-132

Chiavacci, E., D'Aurizio, R., Guzzolino, E., Russo, F., Baumgart, M., Groth, M., Mariani, L., D'Onofrio, M., Arisi, I., Pellegrini, M., Cellerino, A., Cremisi, F., Pitto, L. (2015) MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome. Scientific Reports. 5:18240

Baumgart, M., Groth, M., Priebe, S., Savino, A., Testa, G., Dix, A., Ripa, R., Spallotta, F., Gaetano, C., Ori, M., Terzibasi Tozzini, E., Guthke, R., Platzer, M., Cellerino, A. (2014) RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. Aging Cell. 13(6):965-74

Chiavacci, E., Cremisi, F., Guzzolino, E., Cellerino, A., Baumgart, M., D'aurizio, R., Pitto, L. (2014) miR-19a replacement rescues cardiac and fin defects in zebrafish model of Holt-Oram Syndrome. Cardiovascular research. 103 Suppl 1:S99

Terzibasi Tozzini, E., Baumgart, M., Battistoni, G., and Cellerino, A. (2012) Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging. Aging Cell. 11(2):241-251

Reichwald, K., Lauber, C., Nanda, I., Kirschner, J., Hartmann, N., Schories, S., Gausmann, U., Taudien, S., Schilhabel, M.B., Szafranski, K., Glockner, G., Schmid, M., Cellerino, A., Schartl, M., Englert, C., and Platzer, M. (2009) High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. Genome biology. 10(2):R16