| Term: | macrophage pyroptotic inflammatory response |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | macrophage |
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| Synonyms: | histiocyte |
| Definition: | A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. |
| Ontology: | Anatomy Ontology [ZFA:0009141] |
| Name: | pyroptotic inflammatory response |
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| Synonyms: | pyroptosis |
| Definition: | A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death. |
| Ontology: | GO: Biological Process [GO:0070269] QuickGO AmiGO |