Gene
tenm3
- ID
- ZDB-GENE-990714-19
- Name
- teneurin transmembrane protein 3
- Symbol
- tenm3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within dendrite guidance; retinal ganglion cell axon guidance; and visual perception. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including fin bud; immature eye; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human TENM3 (teneurin transmembrane protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb399 (23 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kg69 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| la013653Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013654Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013655Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021165Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021166Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021168Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021169Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028143Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028144Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tenm3 | China Zebrafish Resource Center (CZRC) | |
| MO1-tenm3 | N/A | Antinucci et al., 2013 |
| MO2-tenm3 | N/A | Antinucci et al., 2013 |
| TALEN1-tenm3 | Antinucci et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Carboxypeptidase-like, regulatory domain superfamily | EGF-like domain | Quinoprotein amine dehydrogenase, beta chain-like | RHS repeat | Rhs repeat-associated core | Six-bladed beta-propeller, TolB-like | Teneurin | Teneurin intracellular, N-terminal | Tox-GHH domain | YD repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W7R4 | InterPro | 2694 | ||||||||||
| UniProtKB:A0AB13A3M7 | InterPro | 2716 | ||||||||||
| UniProtKB:A0AB32TR24 | InterPro | 2812 | ||||||||||
| UniProtKB:A0AB32TRI1 | InterPro | 2645 | ||||||||||
| UniProtKB:A0AB32TSR7 | InterPro | 2447 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(tenm3:GAL4FF) |
|
| 1 | Antinucci et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-42A2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-79C1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-214H9 | ZFIN Curated Data | |
| Contained in | BAC | RP71-38B8 | ZFIN Curated Data | |
| Encodes | EST | cb399 | Thisse et al., 2001 | |
| Encodes | EST | ibd3379 | ||
| Encodes | EST | fc68f07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153720 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001365543 (1) | 12012 nt | ||
| Genomic | GenBank:BX957306 (1) | 224487 nt | ||
| Polypeptide | UniProtKB:A0AB32TXV6 (1) | 2827 aa |
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Cheung, A., Trevers, K.E., Reyes-Corral, M., Antinucci, P., Hindges, R. (2019) Expression and Roles of Teneurins in Zebrafish. Frontiers in neuroscience. 13:158
- Kim, J., Kim, C.Y., Oh, H., Ryu, B., Kim, U., Lee, J.M., Jung, C.R., Park, J.H. (2018) Trimethyltin chloride induces reactive oxygen species-mediated apoptosis in retinal cells during zebrafish eye development. The Science of the total environment. 653:36-44
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, X., Lin, J., Li, F., Zhang, C., Li, J., Wang, C., Dahlgren, R.A., Zhang, H., Wang, H. (2017) Screening and functional identification of lncRNAs under β-diketone antibiotic exposure to zebrafish (Danio rerio) using high-throughput sequencing. Aquatic toxicology (Amsterdam, Netherlands). 182:214-225
- Antinucci, P., Suleyman, O., Monfries, C., Hindges, R. (2016) Neural Mechanisms Generating Orientation Selectivity in the Retina. Current biology : CB. 26(14):1802-15
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Antinucci, P., Nikolaou, N., Meyer, M.P., and Hindges, R. (2013) Teneurin-3 specifies morphological and functional connectivity of retinal ganglion cells in the vertebrate visual system. Cell Reports. 5(3):582-592
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ritter, D.I., Dong, Z., Guo, S., and Chuang, J.H. (2012) Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 7(5):e35202
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