Gene
hoxd4a
- ID
- ZDB-GENE-980526-214
- Name
- homeobox D4a
- Symbol
- hoxd4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blood vessel morphogenesis and hemopoiesis. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including embryonic structure; nervous system; neural keel; neural plate; and vasculature. Orthologous to human HOXD4 (homeobox D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu419 (23 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016502Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa30912 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3363 | Allele with one delins | Exon 1 | Frameshift | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxd4a | Zhang et al., 2020 | |
| MO1-hoxd4a | N/A | (2) |
| MO2-hoxd4a | N/A | (2) |
| MO3-hoxd4a | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Antp homeobox family, Deformed subfamily | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:O57374 | InterPro | 236 | |||||||
| UniProtKB:B0S5Y5 | InterPro | 256 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxd4a-201
(1)
|
Ensembl | 2,288 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(1.1hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(-1.7hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(-2.3hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(-2.8hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(-4.5hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(5.6hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(6.3hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(7.7hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(-8.3hoxd4a:GFP) |
|
| 1 | (2) | |
| Tg(-10.1hoxd4a:GFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-78H1 | ZFIN Curated Data | |
| Contains | SNP | rs3728207 | Stickney et al., 2002 | |
| Contains | SNP | rs3728208 | Stickney et al., 2002 | |
| Encodes | EST | eu419 | Thisse et al., 2005 | |
| Encodes | EST | fb36c05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194402 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194421 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194711 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126445 (1) | 1247 nt | ||
| Genomic | GenBank:BX322661 (1) | 146527 nt | ||
| Polypeptide | UniProtKB:B0S5Y5 (1) | 256 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | HOXD4 | 2 | Amino acid sequence comparison (6) Conserved genome location (synteny) (3) Nucleotide sequence comparison (1) | |
| Mouse | Hoxd4 | 2 | Functional complementation (1) Amino acid sequence comparison (3) Nucleotide sequence comparison (1) Conserved genome location (synteny) (1) |
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Franke, M., De la Calle-Mustienes, E., Neto, A., Almuedo-Castillo, M., Irastorza-Azcarate, I., Acemel, R.D., Tena, J.J., Santos-Pereira, J.M., Gómez-Skarmeta, J.L. (2021) CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression. Nature communications. 12:5415
- Howard, A.G., Baker, P.A., Ibarra-García-Padilla, R., Moore, J.A., Rivas, L.J., Tallman, J.J., Singleton, E.W., Westheimer, J.L., Corteguera, J.A., Uribe, R.A. (2021) An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. eLIFE. 10:
- Matharu, N.K., Yadav, S., Kumar, M., Mishra, R.K. (2021) Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish. Cells & development. 166:203682
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Quintanilla, C.A., Ho, R.K. (2020) The Cdx transcription factors and retinoic acid play parallel roles in antero-posterior position of the pectoral fin field during gastrulation. Mechanisms of Development. 164:103644
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