Gene
jak2b
- ID
- ZDB-GENE-980526-123
- Name
- Janus kinase 2b
- Symbol
- jak2b Nomenclature History
- Previous Names
-
- Jak2b kinase
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in cell differentiation; cell surface receptor signaling pathway; and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytosol. Is expressed in several structures, including lateral line; lens; mandibular arch skeleton; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| Budd-Chiari syndrome | Alliance | {Budd-Chiari syndrome, somatic} | 600880 |
| essential thrombocythemia | Alliance | Thrombocythemia 3 | 614521 |
| familial erythrocytosis 1 | Alliance | Erythrocytosis, somatic | 133100 |
| myelofibrosis | Alliance | Myelofibrosis, somatic | 254450 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | FERM superfamily, second domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK2, FERM domain C-lobe | JAK, FERM F2 lobe domain | Janus Kinase (JAK) | PH-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase JAK2, SH2 domain | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z6T4 | InterPro | 954 | ||||||||||||||||||||
| UniProtKB:C0RW38 | InterPro | 1126 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available