Gene
mast1b
- ID
- ZDB-GENE-131025-2
- Name
- microtubule associated serine/threonine kinase 1b
- Symbol
- mast1b Nomenclature History
- Previous Names
-
- id:ibd3427
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in brain development; cytoskeleton organization; and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in microtubule cytoskeleton and neuronal cell body. Is expressed in hindbrain; midbrain; spinal cord; telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in female breast cancer and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations | Alliance | Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations | 618273 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR015022 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain |
| Domain | IPR037711 | Microtubule-associated serine/threonine-protein kinase, catalytic domain |
| Family | IPR050236 | Serine/threonine-protein kinases, AGC |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR023142 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Microtubule-associated serine/threonine-protein kinase, catalytic domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily | PDZ domain | PDZ superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AXQ6 | InterPro | 1634 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mast1b-201
(1)
|
Ensembl | 4,776 nt | ||
| mRNA |
mast1b-202
(1)
|
Ensembl | 7,288 nt | ||
| mRNA |
mast1b-203
(1)
|
Ensembl | 2,310 nt | ||
| mRNA |
mast1b-204
(1)
|
Ensembl | 4,722 nt | ||
| mRNA |
mast1b-205
(1)
|
Ensembl | 4,764 nt | ||
| mRNA |
mast1b-206
(1)
|
Ensembl | 1,422 nt | ||
| mRNA |
mast1b-207
(1)
|
Ensembl | 4,581 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance