Gene

cers3a

ID

ZDB-GENE-130320-1

Name

ceramide synthase 3a

Symbol

cers3a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum; membrane; and nucleus. Is expressed in several structures, including digestive system; immature eye; intermediate cell mass of mesoderm; myotome; and pectoral fin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to human CERS3 (ceramide synthase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Brondolin et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cers3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive congenital ichthyosis 9	Alliance	Ichthyosis, congenital, autosomal recessive 9	615023

Associated With cers3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeodomain
Domain	IPR006634	TRAM/LAG1/CLN8 homology domain
Family	IPR016439	Sphingosine N-acyltransferase Lag1/Lac1-like
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q8A3	InterPro	208
UniProtKB:A0A8M9Q249	InterPro	293
UniProtKB:A0A140LFW4	InterPro	380
UniProtKB:A0AB32TUP0	InterPro	403

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cers3a-201 (1) Ensembl	Ensembl	1,053 nt	Select Tool ZFIN BLAST
mRNA	cers3a-202 (1) Ensembl	Ensembl	4,937 nt	Select Tool ZFIN BLAST
mRNA	cers3a-203 (1) Ensembl	Ensembl	1,032 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations