Gene
sting1
- ID
- ZDB-GENE-120921-1
- Name
- stimulator of interferon response cGAMP interactor 1
- Symbol
- sting1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and proton channel activity. Involved in positive regulation of macroautophagy. Acts upstream of or within several processes, including positive regulation of non-canonical NF-kappaB signal transduction; regulation of defense response; and regulation of type I interferon production. Located in endoplasmic reticulum. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| STING-associated vasculopathy with onset in infancy | Alliance | STING-associated vasculopathy, infantile-onset | 615934 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR047191 | Stimulator of interferon genes protein, C-terminal |
| Domain | IPR055432 | STING, ligand-binding domain |
| Domain | IPR055434 | STING, transmembrane domain |
| Family | IPR029158 | Stimulator of interferon genes protein |
| Homologous_superfamily | IPR038623 | Stimulator of interferon genes protein, C-terminal domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Stimulator of interferon genes protein | Stimulator of interferon genes protein, C-terminal | Stimulator of interferon genes protein, C-terminal domain superfamily | STING, ligand-binding domain | STING, transmembrane domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7F4N7 | InterPro PDB | 398 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sting1-202
(1)
|
Ensembl | 1,699 nt | ||
| mRNA |
tmem173-201
(1)
|
Ensembl | 1,583 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids