Gene
dock6
- ID
- ZDB-GENE-120411-11
- Name
- dedicator of cytokinesis 6
- Symbol
- dock6 Nomenclature History
- Previous Names
-
- si:dkey-114l24.1
- unm_sa1010
- unm_sa899
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Adams-Oliver syndrome | Alliance | Adams-Oliver syndrome 2 | 614219 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR021816 | Dedicator of cytokinesis C/D, N-terminal |
| Domain | IPR027007 | C2 DOCK-type domain |
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR037808 | Dedicator of cytokinesis C, C2 domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis C, C2 domain | Dedicator of cytokinesis C/D, N-terminal | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TJI2 | InterPro | 2085 | |||||||||||
| UniProtKB:A0AB32TJM6 | InterPro | 2114 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance