Gene

fgd4b

ID

ZDB-GENE-110421-6

Name

FYVE, RhoGEF and PH domain containing 4b

Symbol

fgd4b Nomenclature History

Previous Names

sb:eu921

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity and metal ion binding activity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu921 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgd4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 4H	Alliance	Charcot-Marie-Tooth disease, type 4H	609311

Associated With fgd4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000306	FYVE zinc finger
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR035941	FGD1-4, C-terminal PH domain
Domain	IPR037742	FGD4, N-terminal PH domain
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	FGD1-4, C-terminal PH domain	FGD4, N-terminal PH domain	FYVE zinc finger	PH-like domain superfamily	Pleckstrin homology domain	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:E7EYW1 InterPro	653
UniProtKB:A0A8M1PU37 InterPro	775

Transcripts

Genome Browsers: No data available

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations