Gene
kif21a
- ID
- ZDB-GENE-110411-237
- Name
- kinesin family member 21A
- Symbol
- kif21a Nomenclature History
- Previous Names
-
- si:ch1073-222m2.1
- si:ch211-114o15.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within glomerular filtration and podocyte differentiation. Predicted to be located in cytoskeleton; dendrite; and growth cone. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in liver; nervous system; pleuroperitoneal region; and somite. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Riedmann et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Riedmann et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital fibrosis of the extraocular muscles 1 | Alliance | Fibrosis of extraocular muscles, congenital, 1 | 135700 |
| congenital fibrosis of the extraocular muscles 1 | Alliance | Fibrosis of extraocular muscles, congenital, 3B | 135700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Domain | IPR056532 | KIF21A/B, second helical domain |
| Domain | IPR056533 | KIF21A/B, first helical domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | KIF21A/B, first helical domain | KIF21A/B, second helical domain | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Quinoprotein alcohol dehydrogenase-like superfamily | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWT6 | InterPro | 1591 | ||||||||||||
| UniProtKB:A0A8M3APB0 | InterPro | 1575 | ||||||||||||
| UniProtKB:A0A8M2BAB6 | InterPro | 1597 | ||||||||||||
| UniProtKB:F8W409 | InterPro | 1598 | ||||||||||||
| UniProtKB:A0A8M9PNH0 | InterPro | 1597 | ||||||||||||
| UniProtKB:A0A8M2BAD0 | InterPro | 1554 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kif21a-201
(1)
|
Ensembl | 8,220 nt | ||
| mRNA |
kif21a-202
(1)
|
Ensembl | 4,584 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-kif21a | polyclonal | IgG | Rabbit |
|
Biorbyt LLC
|
2 |
Plasmids
No data available