Gene
angpt4
- ID
- ZDB-GENE-110104-1
- Name
- angiopoietin 4
- Symbol
- angpt4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPT4 (angiopoietin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3879 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-angpt4 | Wu et al., 2023 | |
| CRISPR2-angpt4 | Wu et al., 2023 | |
| CRISPR3-angpt4 | Wu et al., 2023 | |
| CRISPR4-angpt4 | Wu et al., 2023 | |
| TALEN1-angpt4 | Xiao et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR050373 | Fibrinogen C-terminal domain-containing protein |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen, conserved site | Fibrinogen C-terminal domain-containing protein | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:X1WC45 | InterPro | 496 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angpt4-201
(1)
|
Ensembl | 2,245 nt | ||
| mRNA |
angpt4-202
(1)
|
Ensembl | 1,500 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myl7:EGFP-angpt4) |
|
| 1 | Wu et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220D10 | ||
| Contained in | BAC | DKEY-233K3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005166270 (1) | 3620 nt | ||
| Genomic | GenBank:BX324124 (2) | 126152 nt | ||
| Polypeptide | UniProtKB:X1WC45 (1) | 496 aa |
- Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.P., Zhu, Z., Xiong, J.W., Tong, X., Zhang, Y., Wang, S., Tang, F., Zhang, B. (2023) Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein & cell. 14:350368350-368
- Wang, X., Ren, Y., Li, J., Ji, Z., Chen, F., Wang, X. (2020) Identification of the 14-3-3 β/α-A protein as a novel maternal peptidoglycan-binding protein that protects embryos of zebrafish against bacterial infections. Developmental and comparative immunology. 114:103867
- Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141
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