Gene
arfgef2
- ID
- ZDB-GENE-090312-50
- Name
- ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
- Symbol
- arfgef2 Nomenclature History
- Previous Names
-
- si:dkey-192i18.4
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within with a positive effect on angioblast cell migration and cell migration involved in sprouting angiogenesis. Predicted to be located in Golgi apparatus; membrane; and perinuclear region of cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ARF guanine nucleotide exchange factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Lu et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| periventricular nodular heterotopia | Alliance | Periventricular heterotopia with microcephaly | 608097 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000904 | Sec7 domain |
| Domain | IPR015403 | Mon2/Sec7/BIG1-like, HDS |
| Domain | IPR032629 | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain |
| Domain | IPR032691 | Mon2/Sec7/BIG1-like, HUS domain |
| Domain | IPR046455 | Sec7/BIG1-like, C-terminal domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR023394 | Sec7, C-terminal domain superfamily |
| Homologous_superfamily | IPR035999 | Sec7 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain | Mon2/Sec7/BIG1-like, HDS | Mon2/Sec7/BIG1-like, HUS domain | Sec7/BIG1-like, C-terminal domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FCG1 | InterPro | 1846 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arfgef2-201
(1)
|
Ensembl | 5,541 nt | ||
| mRNA |
arfgef2-202
(1)
|
Ensembl | 5,909 nt |
Interactions and Pathways
No data available
Plasmids
No data available