Gene
calhm1a
- ID
- ZDB-GENE-081107-71
- Name
- calcium homeostasis modulator 1a
- Symbol
- calhm1a Nomenclature History
- Previous Names
-
- calhm1 (1)
- si:dkey-51a16.6
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables voltage-gated calcium channel activity. Acts upstream of or within calcium ion transmembrane transport. Is active in plasma membrane. Orthologous to human CALHM1 (calcium homeostasis modulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12855 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR029569 | Calcium homeostasis modulator family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium homeostasis modulator family |
|---|---|---|---|
| UniProtKB:E7F2J4 | InterPro PDB | 346 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
calhm1-201
(1)
|
Ensembl | 1,041 nt | ||
| mRNA |
calhm1-202
(1)
|
Ensembl | 3,309 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51A16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017358898 (1) | |||
| Genomic | GenBank:BX530079 (1) | 166397 nt | ||
| Polypeptide | UniProtKB:E7F2J4 (1) | 346 aa |
- Ren, Y., Li, Y., Wang, Y., Wen, T., Lu, X., Chang, S., Zhang, X., Shen, Y., Yang, X. (2022) Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel. The Journal of biological chemistry. 298(5):101838
- Ren, Y., Wen, T., Xi, Z., Li, S., Lu, J., Zhang, X., Yang, X., Shen, Y. (2020) Cryo-EM structure of the calcium homeostasis modulator 1 channel. Science advances. 6:eaba8161
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Le Faou, P., Völkel, P., and Angrand, P.O. (2011) The zebrafish genes encoding the Polycomb Repressive Complex (PRC) 1. Gene. 475(1):10-21
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