Gene
hsd3b1
- ID
- ZDB-GENE-081105-30
- Name
- hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
- Symbol
- hsd3b1 Nomenclature History
- Previous Names
-
- si:rp71-68n21.10
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity. Acts upstream of or within pigmentation. Is expressed in brain; endocrine system; and gonad primordium. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to several human genes including HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1).
- Genome Resources
- Note
-
This gene is orthologous to both human HSD3B1 and HSD3B2
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 3-beta hydroxysteroid dehydrogenase/isomerase | Bifunctional lipid A modification and metabolic enzymes | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PLD3 | InterPro | 311 | |||
| UniProtKB:F1QSA2 | InterPro | 374 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsd3b1-201
(1)
|
Ensembl | 1,535 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-68N21 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001386297 (1) | |||
| Genomic | GenBank:CU151884 (1) | 200118 nt | ||
| Polypeptide | UniProtKB:F1QSA2 (1) | 374 aa |
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Zhai, G., Shu, T., Yu, G., Tang, H., Shi, C., Jia, J., Lou, Q., Dai, X., Jin, X., He, J., Xiao, W., Liu, X., Yin, Z. (2022) Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLIFE. 11:
- Crespo, D., Assis, L.H.C., Zhang, Y.T., Safian, D., Furmanek, T., Skaftnesmo, K.O., Norberg, B., Ge, W., Choi, Y.C., den Broeder, M.J., Legler, J., Bogerd, J., Schulz, R.W. (2021) Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells. Communications biology. 4:204
- Wang, Y., Ye, D., Zhang, F., Zhang, R., Zhu, J., Wang, H., He, M., Sun, Y. (2021) Cyp11a2 is essential for oocyte development and spermatogonial stem cell differentiation in zebrafish. Endocrinology. 163(2):
- Yan, Y.L., Titus, T., Desvignes, T., BreMiller, R., Batzel, P., Sydes, J., Farnsworth, D., Dillon, D., Wegner, J., Phillips, J.B., Peirce, J., Dowd, J., Undiagnosed Diseases Network, Buck, C.L., Miller, A., Westerfield, M., Postlethwait, J.H. (2021) A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs. Genetics. 217(2)
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Xiao, L., Guo, Y., Wang, D., Zhao, M., Hou, X., Li, S., Lin, H., Zhang, Y. (2020) Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Frontiers in genetics. 11:161
- Zayed, Y., Malik, R., Qi, X., Peng, C. (2020) Nodal regulates ovarian functions in zebrafish. Molecular and Cellular Endocrinology. 511:110821
- Chen, H., Feng, W., Chen, K., Qiu, X., Xu, H., Mao, G., Zhao, T., Ding, Y., Wu, X. (2019) Transcriptomic analysis reveals potential mechanisms of toxicity in a combined exposure to dibutyl phthalate and diisobutyl phthalate in zebrafish (Danio rerio) ovary. Aquatic toxicology (Amsterdam, Netherlands). 216:105290
1 - 10 of 22
Show