Gene
prf1.5
- ID
- ZDB-GENE-081105-3
- Name
- perforin 1.5
- Symbol
- prf1.5 Nomenclature History
- Previous Names
-
- prf8a (1)
- si:ch211-103n10.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable wide pore channel activity. Predicted to be involved in T cell mediated cytotoxicity; defense response to virus; and immunological synapse formation. Predicted to act upstream of or within killing of cells of another organism and leukocyte mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be active in membrane. Is expressed in gill; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Domain | IPR037300 | Perforin-1, C2 domain |
| Family | IPR052784 | Perforin-1 pore-forming |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Perforin-1, C2 domain | Perforin-1 pore-forming |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UYU9 | InterPro | 517 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prf1.5-201
(1)
|
Ensembl | 1,643 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-103N10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123246 (1) | 1576 nt | ||
| Genomic | GenBank:BX005025 (1) | 196375 nt | ||
| Polypeptide | UniProtKB:A0A8N7UYU9 (1) | 517 aa |
No data available
- Fu, X., Chen, Y., Wang, L., Zhou, Q., Li, M., Song, Y., Li, Y., Zhao, F., Chen, S. (2021) Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Developmental and comparative immunology. 122:104135
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Varela, M., Forn-Cuní, G., Dios, S., Figueras, A., Novoa, B. (2016) Proinflammatory Caspase A Activation and an Antiviral State Are Induced by a Zebrafish Perforin after Possible Cellular and Functional Diversification from a Myeloid Ancestor. Journal of Innate Immunity. 8(1):43-56
- Benard, E.L., Racz, P.I., Rougeot, J., Nezhinsky, A.E., Verbeek, F.J., Spaink, H.P., Meijer, A.H. (2015) Macrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish. Journal of Innate Immunity. 7(2):136-52
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