Gene
gata1b
- ID
- ZDB-GENE-081104-43
- Name
- GATA binding protein 1b
- Symbol
- gata1b Nomenclature History
- Previous Names
-
- si:dkeyp-77f7.5
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate commitment; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); bone marrow cancer (multiple); colon adenocarcinoma; depressive disorder; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pimtong et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 9 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 9 | 301083 |
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked, with or without dyserythropoietic anemia | 300367 |
| transient myeloproliferative syndrome | Alliance | Leukemia, megakaryoblastic, with or without Down syndrome, somatic | 159595 |
| X-linked dyserythropoietic anemia | Alliance | Anemia, X-linked, with/without neutropenia and/or platelet abnormalities | 300835 |
| X-linked thrombocytopenia with beta-thalassemia | Alliance | Thrombocytopenia with beta-thalassemia, X-linked | 314050 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QAH1 | InterPro | 372 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata1b-201
(1)
|
Ensembl | 1,086 nt | ||
| mRNA |
gata1b-202
(1)
|
Ensembl | 887 nt |
Interactions and Pathways
No data available
Plasmids
No data available