Gene
ep300b
- ID
- ZDB-GENE-080403-15
- Name
- E1A binding protein p300 b
- Symbol
- ep300b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and ventricular zone. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017642 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a361 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa6888 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6889 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20005 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26061 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31327 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31328 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33172 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33173 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ep300b | Thyme et al., 2019 | |
| CRISPR2-ep300b | Thyme et al., 2019 | |
| CRISPR3-ep300b | Thyme et al., 2019 | |
| CRISPR4-ep300b | Thyme et al., 2019 | |
| MO1-ep300b | N/A | Huang et al., 2013 |
| MO2-ep300b | N/A | Babu et al., 2018 |
| MO3-ep300b | N/A | Babu et al., 2018 |
| MO4-ep300b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Rubinstein-Taybi syndrome | Alliance | Rubinstein-Taybi syndrome 2 | 613684 |
| Menke-Hennekam syndrome 2 | 618333 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | CBP/p300, atypical RING domain superfamily | CBP/p300-type histone acetyltransferase domain | Coactivator CBP, KIX domain | Coactivator CBP, KIX domain superfamily | CREB-binding protein/p300, atypical RING domain | Histone acetyltransferase p300/CREBBP, PHD domain | Histone acetyltransferase Rtt109/CBP | Nuclear receptor coactivator, CREB-bp-like, interlocking | Nuclear receptor coactivator, interlocking | TAZ domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, TAZ-type | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AXZ0 | InterPro | 2617 | |||||||||||||||||
| UniProtKB:A0A8M3B890 | InterPro | 2636 | |||||||||||||||||
| UniProtKB:A0A8M3B0W3 | InterPro | 2645 | |||||||||||||||||
| UniProtKB:A0A8M3AQU7 | InterPro | 2635 | |||||||||||||||||
| UniProtKB:A0A8M3AQI0 | InterPro | 2639 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ep300b-201
(1)
|
Ensembl | 7,728 nt | ||
| mRNA |
ep300b-202
(1)
|
Ensembl | 10,791 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-369F20 | ||
| Contained in | BAC | CH211-280J3 | ||
| Contained in | BAC | DKEY-271F3 | ||
| Encodes | EST | dq017642 | Bertrand et al., 2007 | |
| Encodes | EST | fj84f01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009299407 (1) | 10912 nt | ||
| Genomic | GenBank:AL954851 (1) | 177221 nt | ||
| Polypeptide | UniProtKB:A0A8M3AQU5 (1) | 2646 aa |
- Zhou, W.H., Luo, Y., Li, R.X., Degrace, P., Jourdan, T., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2023) Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of raptor in zebrafish. The Journal of biological chemistry. 299(10):105220
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Park, J.E., Kim, E., Lee, D.W., Park, T.K., Kim, M.S., Jang, S.Y., Ahn, J., Park, K.B., Kim, K.H., Park, H.C., Ki, C.S., Kim, D.K. (2021) Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly. Scientific Reports. 11:15931
- Shimizu, Y., Kawasaki, T. (2021) Histone acetyltransferase EP300 regulates the proliferation and differentiation of neural stem cells during adult neurogenesis and regenerative neurogenesis in the zebrafish optic tectum. Neuroscience letters. 756:135978
- Wang, X., Yan, J. (2020) Directional divergence of Ep300 duplicates in teleosts and its implications. BMC Evolutionary Biology. 20:140
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Babu, A., Kamaraj, M., Basu, M., Mukherjee, D., Kapoor, S., Ranjan, S., Swamy, M.M., Kaypee, S., Scaria, V., Kundu, T.K., Sachidanandan, C. (2018) Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi syndrome in zebrafish. Biochimica et biophysica acta. 1864(4 Pt A):1203-1215
- Zhang, B., Wu, X., Zhang, W., Shen, W., Sun, Q., Liu, K., Zhang, Y., Wang, Q., Li, Y., Meng, A., Xie, W. (2018) Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Molecular Cell. 72:673-686.e6
- Bajanca, F., Vandel, L. (2017) Epigenetic Regulators Modulate Muscle Damage in Duchenne Muscular Dystrophy Model. PLoS Currents. 9
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