Gene
ugt1b3
- ID
- ZDB-GENE-080227-12
- Name
- UDP glucuronosyltransferase 1 family, polypeptide B3
- Symbol
- ugt1b3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in intestine; kidney; and liver. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1) and UGT1A5 (UDP glucuronosyltransferase family 1 member A5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | UDP-glucuronosyl/UDP-glucosyltransferase | UDP-glycosyltransferase | UDP-glycosyltransferase family, conserved site |
|---|---|---|---|---|---|
| UniProtKB:F1RCH0 | InterPro | 535 | |||
| UniProtKB:D3XD63 | InterPro | 535 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ugt1b3-201
(1)
|
Ensembl | 1,728 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31D5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177346 (1) | 1728 nt | ||
| Genomic | GenBank:BX323548 (1) | 222367 nt | ||
| Polypeptide | UniProtKB:D3XD63 (1) | 535 aa |
No data available
- Yang, H., Huang, Y., Li, Z., Guo, Y., Li, S., Huang, H., Yang, X., Li, G., Chen, H. (2022) Effects of Dietary Supplementation with Aurantiochytrium sp. on Zebrafish Growth as Determined by Transcriptomics. Animals : an open access journal from MDPI. 12(20):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Christen, V., Fent, K. (2014) Tissue-, sex- and development-specific transcription profiles of eight UDP-glucuronosyltransferase genes in zebrafish (Danio rerio) and their regulation by activator of aryl hydrocarbon receptor. Aquatic toxicology (Amsterdam, Netherlands). 150:93-102
- Wang, Y., Huang, H., Wu, Q. (2014) Characterization of the Zebrafish Ugt Repertoire Reveals a New Class of Drug-metabolizing UDP Glucuronosyltransferases. Molecular pharmacology. 86(1):62-75
- Huang, H., and Wu, Q. (2010) Cloning and comparative analyses of the zebrafish ugt repertoire reveal its evolutionary diversity. PLoS One. 5(2):e9144
- Li, C., and Wu, Q. (2007) Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evolutionary Biology. 7(1):69
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