Gene
ugt1b2
- ID
- ZDB-GENE-080227-11
- Name
- UDP glucuronosyltransferase 1 family, polypeptide B2
- Symbol
- ugt1b2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables glucuronosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in intestine; kidney; liver; and muscle. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1) and UGT1A5 (UDP glucuronosyltransferase family 1 member A5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | UDP-glucuronosyl/UDP-glucosyltransferase | UDP-glycosyltransferase | UDP-glycosyltransferase family, conserved site |
|---|---|---|---|---|---|
| UniProtKB:F1QYW1 | InterPro | 531 | |||
| UniProtKB:D3XD61 | InterPro | 531 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ugt1b2-201
(1)
|
Ensembl | 1,715 nt | ||
| mRNA |
ugt1b2-202
(1)
|
Ensembl | 1,451 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31D5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-245J21 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177336 (1) | 1715 nt | ||
| Genomic | GenBank:BX323548 (1) | 222367 nt | ||
| Polypeptide | UniProtKB:D3XD61 (1) | 531 aa |
No data available
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ma, Y.N., Cao, C.Y., Wang, Q.W., Gui, W.J., Zhu, G.N. (2016) Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 179:55-64
- Christen, V., Fent, K. (2014) Tissue-, sex- and development-specific transcription profiles of eight UDP-glucuronosyltransferase genes in zebrafish (Danio rerio) and their regulation by activator of aryl hydrocarbon receptor. Aquatic toxicology (Amsterdam, Netherlands). 150:93-102
- Fent, K., Chew, G., Li, J., Gomez, E. (2014) Benzotriazole UV-stabilizers and benzotriazole: Antiandrogenic activity in vitro and activation of aryl hydrocarbon receptor pathway in zebrafish eleuthero-embryos. The Science of the total environment. 482-483:125-36
- Wang, Y., Huang, H., Wu, Q. (2014) Characterization of the Zebrafish Ugt Repertoire Reveals a New Class of Drug-metabolizing UDP Glucuronosyltransferases. Molecular pharmacology. 86(1):62-75
- Huang, H., and Wu, Q. (2010) Cloning and comparative analyses of the zebrafish ugt repertoire reveal its evolutionary diversity. PLoS One. 5(2):e9144
- Li, C., and Wu, Q. (2007) Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evolutionary Biology. 7(1):69
1 - 7 of 7
Show