Gene
zeb1a
- ID
- ZDB-GENE-070912-124
- Name
- zinc finger E-box binding homeobox 1a
- Symbol
- zeb1a Nomenclature History
- Previous Names
-
- si:ch211-159p3.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and metal ion binding activity. Involved in regulation of cell-cell adhesion involved in gastrulation and smooth muscle tissue development. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Is expressed in hypoblast and neural plate. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gays et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 6 | 613270 |
| posterior polymorphous corneal dystrophy 3 | Alliance | Corneal dystrophy, posterior polymorphous, 3 | 609141 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:F1QMZ5
|
1190 | ||
|
UniProtKB:F1QBD3
|
1176 |
Interactions and Pathways
No data available
Plasmids
No data available