ZFIN is now using GRCz12tu for Genomic Data
Gene
tnrc6bb.1
- ID
- ZDB-GENE-070705-475
- Name
- trinucleotide repeat containing adaptor 6Bb.1
- Symbol
- tnrc6bb.1 Nomenclature History
- Previous Names
-
- tnrc6bb.2
- si:dkey-217f16.6
- si:dkey-46g23.1
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable nucleic acid binding activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within regulation of translation. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in subserous uterine fibroid and uterine fibroid. Orthologous to human TNRC6B (trinucleotide repeat containing adaptor 6B).
- Genome Resources
- Note
-
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Global developmental delay with speech and behavioral abnormalities | 619243 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019486 | Argonaute hook domain |
| Domain | IPR032226 | TNRC6, PABC binding domain |
| Family | IPR052068 | GW182 domain-containing protein |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Argonaute hook domain | GW182 domain-containing protein | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | TNRC6, PABC binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PGS9 | InterPro | 865 | |||||
| UniProtKB:E7F923 | InterPro | 1443 | |||||
| UniProtKB:A0A8M9QAP9 | InterPro | 1410 | |||||
| UniProtKB:A0A286YB96 | InterPro | 1472 | |||||
| UniProtKB:A0A8M9PTX3 | InterPro | 836 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-46g23.1-201
(1)
|
Ensembl | 4,332 nt | ||
| mRNA |
si:dkey-46g23.1-202
(1)
|
Ensembl | 9,907 nt | ||
| mRNA |
si:dkey-46g23.1-203
(1)
|
Ensembl | 4,419 nt | ||
| mRNA |
si:dkey-217f16.6-201
(1)
|
Ensembl | 2,757 nt | ||
| mRNA |
si:dkey-217f16.6-202
(1)
|
Ensembl | 832 nt | ||
| mRNA |
si:dkey-217f16.6-203
(1)
|
Ensembl | 2,670 nt |
Interactions and Pathways
No data available
Plasmids
No data available