Gene
kremen1
- ID
- ZDB-GENE-070705-262
- Name
- kringle containing transmembrane protein 1
- Symbol
- kremen1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Acts upstream of or within angiogenesis; lateral line development; and liver development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in lens; midbrain hindbrain boundary; otic vesicle; posterior lateral line primordium; and ventral fin fold. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-kremen1 | N/A | (4) |
| MO2-kremen1 | N/A | (2) |
| MO3-kremen1 | N/A | (2) |
| MO4-kremen1 | N/A | Wada et al., 2013 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia 13 | Alliance | Ectodermal dysplasia 13, hair/tooth type | 617392 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Carbohydrate-binding WSC | CUB domain | Kremen receptor | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ARY7 | InterPro | 451 | ||||||||
| UniProtKB:B0BLV6 | InterPro | 465 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kremen1-201
(1)
|
Ensembl | 2,365 nt | ||
| mRNA |
kremen1-203
(1)
|
Ensembl | 867 nt | ||
| ncRNA |
kremen1-002
(1)
|
Ensembl | 673 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:kremen1-GFP) |
|
| 1 | (2) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-7C9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171555 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114917 (1) | 2392 nt | ||
| Genomic | GenBank:CT737139 (1) | 159336 nt | ||
| Polypeptide | UniProtKB:B0BLV6 (1) | 465 aa |
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Mulvaney, J.F., Thompkins, C., Noda, T., Nishimura, K., Sun, W.W., Lin, S.Y., Coffin, A., Dabdoub, A. (2016) Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line. Scientific Reports. 6:31668
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- McGraw, H.F., Culbertson, M.D., Nechiporuk, A.V. (2014) Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish. Development (Cambridge, England). 141(16):3212-21
- Lu, H., Ma, J., Yang, Y., Shi, W., and Luo, L. (2013) EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development. Developmental Cell. 24(5):543-553
- Wada, H., Ghysen, A., Asakawa, K., Abe, G., Ishitani, T., and Kawakami, K. (2013) Wnt/Dkk Negative Feedback Regulates Sensory Organ Size in Zebrafish. Current biology : CB. 23(16):1559-65
- Gore, A.V., Swift, M.R., Cha, Y.R., Lo, B., McKinney, M.C., Li, W., Castranova, D., Davis, A., Mukouyama, Y.S., and Weinstein, B.M. (2011) Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (Cambridge, England). 138(22):4875-4886
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 8 of 8
Show