ZFIN is now using GRCz12tu for Genomic Data
Gene
vps4a
- ID
- ZDB-GENE-060929-388
- Name
- vacuolar protein sorting 4 homolog A
- Symbol
- vps4a Nomenclature History
- Previous Names
-
- zgc:153907
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP hydrolysis activity. Predicted to be involved in endosomal transport and vacuole organization. Predicted to be located in endosome membrane. Orthologous to human VPS4A (vacuolar protein sorting 4 homolog A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Shipman et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| CIMDAG syndrome | 619273 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR007330 | MIT domain |
| Domain | IPR015415 | Spastin/Vps4, C-terminal |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Domain | IPR045253 | Vacuolar protein sorting-associated protein 4, MIT domain |
| Family | IPR050304 | Microtubule-severing AAA ATPase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036181 | MIT domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Microtubule-severing AAA ATPase | MIT domain | MIT domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Spastin/Vps4, C-terminal | Vacuolar protein sorting-associated protein 4, MIT domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08BZ6 | InterPro | 440 | ||||||||||
| UniProtKB:A0A8M3AP98 | InterPro | 436 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers